FIGURE

Figure 4

ID

ZDB-FIG-251125-12

Publication

Toso et al., 2025 - Human and zebrafish mineralocorticoid receptors reporter cell assays to assess the activity of chemicals

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Medrol, drospirenone, progesterone, 11-deoxycortisol, spironolactone and drospirenone had an higher efficacy on zfMR than on hMR

Dose-response curves of medrol (A), drospirenone (B), progesterone (C), 11-deoxycortisol (D), spironolactone (E), and drospirenone (F) in UG5LN-GAL4-hMR and UG5LN-GAL4-zfMR cells. Chemicals were tested alone (agonism test) or in the presence of aldosterone 1 nM in UG5LN-GAL4-hMR cells and 0.5 10⁻⁹ M in UG5LN-GAL4-zfMR cells (antagonism test). Results are expressed as the percentage of the maximum luciferase activity induced by 10⁻⁸ M aldosterone. The curves are presented as a non-linear regression; log (ligand) versus response. EC₅₀ values (10⁻⁹ M) and IC₅₀ values (10⁻⁹ M) are shown in Tables 3 and 4.

Data are presented as means ± SD values. n (replicates per experiment) = 4 per group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience