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Figure 2

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ZDB-FIG-251125-10
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Toso et al., 2025 - Human and zebrafish mineralocorticoid receptors reporter cell assays to assess the activity of chemicals
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Figure 2

Cortisol and dexamethasone had an higherpotency and efficacy on zfMR than on hMR

Dose-response curves of aldosterone, dexamethasone, cortisol, and bimedrazole in UG5LN-GAL4-hMR (A) and UG5LN-GAL4-zfMR cells (B). Results are expressed as the percentage of the maximum luciferase activity induced by 10−8 M aldosterone. The curves are presented as a non-linear regression; log (ligand) versus response. EC50 values (10−9 M) are shown in Tables 3 and 4.

Data are presented as means ± SD values. n (replicates per experiment) = 4 per group.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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