ZFIN Image: Toso et al., 2025, Figure 4

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Figure Caption

Figure 4

Medrol, drospirenone, progesterone, 11-deoxycortisol, spironolactone and drospirenone had an higher efficacy on zfMR than on hMR

Dose-response curves of medrol (A), drospirenone (B), progesterone (C), 11-deoxycortisol (D), spironolactone (E), and drospirenone (F) in UG5LN-GAL4-hMR and UG5LN-GAL4-zfMR cells. Chemicals were tested alone (agonism test) or in the presence of aldosterone 1 nM in UG5LN-GAL4-hMR cells and 0.5 10⁻⁹ M in UG5LN-GAL4-zfMR cells (antagonism test). Results are expressed as the percentage of the maximum luciferase activity induced by 10⁻⁸ M aldosterone. The curves are presented as a non-linear regression; log (ligand) versus response. EC₅₀ values (10⁻⁹ M) and IC₅₀ values (10⁻⁹ M) are shown in Tables 3 and 4.

Data are presented as means ± SD values. n (replicates per experiment) = 4 per group.

Acknowledgments

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