FIGURE

Figure 8

ID

ZDB-FIG-251023-149

Publication

Ameen et al., 2025 - Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

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Figure 8

Inhibition of Notch signalling increases hair cell number after ablation in mutants and control groups (wild-type and gmds +/- siblings). Hair cell YO-PRO-1 counts 48 h post neomycin treatment, with DMSO control group (WT n = 17, +/− n = 27, −/− n = 31) or Notch inhibition with 10 µm DAPT group following ablation (WT n = 6, +/− n = 29, −/− n = 16) (A). Hair cell YO-PRO-1 counts 72 h post neomycin treatment, with DMSO control group (WT n = 18, +/− n = 20, −/− n = 17) or Notch inhibition with 10 µm DAPT treatment following ablation (WT n = 18, +/− n = 34, −/− n = 7) (B). Data presented as mean ± SEM, significance testing using a one-factor ANOVA with Sidak’s multiple comparisons test * p < 0.05, *** p < 0.001, **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gmds^nfl2/nfl2 (AB) gmds^nfl2/+ (AB)
Conditions:	chemical treatment by environment: neomycin chemical treatment by environment: neomycin
Observed In:	neuromast hair cell
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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