FIGURE

Figure 7

ID

ZDB-FIG-251023-148

Publication

Ameen et al., 2025 - Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

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Figure 7

Quantitative assessment of increased hair cell regeneration of gmds^−/− mutants with YO-PRO-1 staining. Data shown were from two independent experiments. At 48 hpa, a trend of increased hair cell number is observed in gmds^−/− mutants, which is statistically significant for the SO3 neuromast (WT SO1 n = 6, Mut SO1 n = 8, WT SO2 n = 7, Mut SO2 n = 7, WT SO3 n = 7, Mut SO3 n = 9, WT O1 n = 9, Mut O1 n = 7, WT O2 n = 7, Mut O2 n = 6) (A,C). By 72 hpa, all assayed neuromasts show a statistically significant increase in hair cell number in gmds^−/− mutants when compared to control siblings (WT SO1 n = 10, Mut SO1 n = 5, WT SO2 n = 12, Mut SO2 n = 13, WT SO3 n = 13, Mut SO3 n = 13, WT O1 n = 13, Mut O1 n = 13, WT O2 n = 12, Mut O2 n = 9) (B,D). Data presented as mean ± SEM, significance testing using a one-factor ANOVA with Sidak’s multiple comparisons test * p < 0.05, ** p < 0.01, **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gmds^nfl2/nfl2 (AB)
Condition:	chemical treatment by environment: neomycin
Observed In:	neuromast hair cell
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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