FIGURE

Figure 4

ID

ZDB-FIG-251023-145

Publication

Ameen et al., 2025 - Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

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Figure 4

Increased neuromast regeneration capacity of gmds^−/− mutants with DASPEI Staining. WT and gmds^−/− mutant unablated neuromasts at 6 dpf from four independent experiments (WT n = 17, gmds^−/− n = 18) (A,B). Wild-type and gmds^−/− mutants show a statistically significant difference in the number of labelled neuromasts 24 h post neomycin ablation. For four experiments, WT n = 17, gmds^−/− n = 19 (C,D,I). A further increase is observed at 48 hpa WT n = 23, gmds^−/− n = 24 (E,F,I) and 72 hpa WT n = 18, gmds^−/− n = 17 (G–I). Control siblings quantified at the same time points show no difference in neuromast number (J). Images taken at 40X. Data presented as mean ± SEM, significance testing using a one-factor ANOVA with Sidak’s multiple comparisons test * p < 0.05, ** p < 0.01, *** p < 0.001. ns = not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gmds^nfl2/nfl2 (AB)
Condition:	chemical treatment by environment: neomycin
Observed In:	neuromast
Stage Range:	Day 4 to Day 6

Phenotype Detail

Acknowledgments

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