FIGURE

Figure 5

ID

ZDB-FIG-251023-146

Publication

Ameen et al., 2025 - Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

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Figure 5

Increased rate of regeneration of larval head neuromasts after neomycin ablation. Neuromasts are morphologically similar in control and gmds^−/− mutants at 5 dpf without neomycin ablation (A,E). Little difference is seen in neuromast morphology at 24 hpa (B,F), but by 48 hpa, neuromast morphology is normal in gmds^−/−, implying complete regeneration (G), while control siblings have not yet fully regenerated (C). By 72 hpa, both control and gmds^−/− neuromasts appear fully regenerated (D,H). Data shown from three experiments for each condition or time post-treatment, WT n = 9, gmds^−/− n = 9. Scalebar in H is 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB gmds^nfl2/nfl2 (AB)
Condition:	chemical treatment by environment: neomycin
Observed In:	neuromast hair cell neuromast hair cell kinocilium neuromast hair cell stereocilium
Stage Range:	Day 4 to Day 6

Phenotype Detail

Acknowledgments

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