FIGURE

Fig. 7

ID

ZDB-FIG-251009-32

Publication

Xiang et al., 2025 - miRNA-130b-3p upregulation impairs osteogenic differentiation in AIS patients by inhibiting the IGF1/ERK pathway

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Fig. 7

miRNA-130b-3p overexpression causes impaired osteogenesis and axial curvature deformity in zebrafish.a. Development of zebrafish embryos after microinjection of miRNA-130b-3p mimic (n = 100) b. Imaging of zebrafish with axial curvature deformity c. Alizarin Red S staining shows delayed vertebral development in zebrafish after miRNA-130b-3p overexpression d. Statistical analysis of vertebral development in zebrafish at day 7(n = 10) e. Expression levels of dre-miR-130b in zebrafish after miRNA-130b-3p mimic microinjection are elevated(n = 5) f. Expression levels of igf1 in zebrafish decrease after miRNA-130b-3p mimic microinjection(n = 5) g. Expression levels of col1a2 in zebrafish decrease after miRNA-130b-3p mimic microinjection(n = 5) h. Expression levels of ocn in zebrafish decrease after miRNA-130b-3p mimic microinjection(n = 5) ***:p<0.001; **:p<0.01; *:p<0.05

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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