FIGURE

Fig. 4

ID

ZDB-FIG-251009-29

Publication

Xiang et al., 2025 - miRNA-130b-3p upregulation impairs osteogenic differentiation in AIS patients by inhibiting the IGF1/ERK pathway

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Fig. 4

mRNA sequencing results of primary osteoblasts from CT group patients before and after overexpression of miRNA-130b-3p. Volcano plot showing gene expression changes, with 460 genes upregulated and 114 genes downregulated Heatmap of the top 20 genes with the most significant differential expression c. KEGG enrichment analysis bubble plot, displaying the top 15 pathways d. KEGG enrichment analysis circular plot e. Prediction of potential target genes of miRNA-130b-3p using the miRTarBase and TargetScan7 databases f. Interaction between miR-130b-3p and two predicted binding sites in the 3’-UTR of IGF1. The miR-130b-3p seed sequence is highlighted in red g. Dual-luciferase assay showing IGF1 as a target gene of miRNA-130b-3p

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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