FIGURE

Fig. 9

ID

ZDB-FIG-250916-30

Publication

Stefan et al., 2025 - Polypharmacology translates between species and phylogenetic distance: A functional, bioinformatic, and structural study on organic anion transporting polypeptides

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Fig. 9

Functional analyses of the 23 pan-ABC transporter modulators against drAbcb4 [39] (A) and murine Abca1 [40,41] (B) determined in rhodamine B and 25-NBD-cholesterol assays, respectively, in zebrafish embryos and murine J774A.1 macrophages, respectively. The compounds were tested at 10 µM (patterned bars) and 50 µM (filled bars) and highly [effect value ≥ 50 % (+SEM); black], moderately [effect value ≥ 20 % (+SEM); gray], and weakly [effect value < 20 % (+SEM); white] active compounds were annotated. Negative (control; white) and positive [CYC, 40 µM (A) and 10 µM (B); blue] responses are shown. Shown are the mean ± SEM values of at least two independent experiments. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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