FIGURE
Fig. 6
- ID
- ZDB-FIG-250916-27
- Publication
- Stefan et al., 2025 - Polypharmacology translates between species and phylogenetic distance: A functional, bioinformatic, and structural study on organic anion transporting polypeptides
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Fig. 6
Structural analyses of human OATP1B1 (PDB IDs 8HNC, 8HND, 8HNH, and 8K6L) and colocalized ligands (A), i.e., bilirubin (BIL; B), 2′,7′-dichlorofluorescein (DCF; C), the pan-SLC transporter modulator estrone sulfate (EST; D), and simeprevir (SIM; E). Additionally shown is the AlphaFold 3-generated [43] structure of drOatp1d1 (UniProt entry A0A8M9PU70; F) with blindly-docked molecules, i.e., BEN (G), DIP (H), MK (I), PRA (J), and BSP (K). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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