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Fig. 9 Functional analyses of the 23 pan-ABC transporter modulators against drAbcb4 [39] (A) and murine Abca1 [40,41] (B) determined in rhodamine B and 25-NBD-cholesterol assays, respectively, in zebrafish embryos and murine J774A.1 macrophages, respectively. The compounds were tested at 10 µM (patterned bars) and 50 µM (filled bars) and highly [effect value ≥ 50 % (+SEM); black], moderately [effect value ≥ 20 % (+SEM); gray], and weakly [effect value < 20 % (+SEM); white] active compounds were annotated. Negative (control; white) and positive [CYC, 40 µM (A) and 10 µM (B); blue] responses are shown. Shown are the mean ± SEM values of at least two independent experiments. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)