FIGURE

Fig. 4

ID

ZDB-FIG-250703-4

Publication

Bullock et al., 2025 - Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma

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Fig. 4

IL-6 drives consistent gene changes in multiple ILC models. (A) Venn diagram of differentially expressed genes in IL-6 treated HCI-013 (green), HCI-018 (purple) ER + ILC PDOs and MM134 (pink) and SUM44PE (orange) ILC cell lines. 64 genes were differentially expressed by IL-6 in all four models. (B) Volcano plot of differential expression of 61 genes in the consensus IL6GS between ER + ILC (n = 191) and ER + NST (n = 563) tumors in the TCGA Firehose dataset. Genes significantly differentially expressed (Wilcoxon U test, FDR < 0.05) and upregulated in ILC (purple) or NST (blue), triangles indicate genes also significantly upregulated by CAF CM in SUM44PE cells. (C) Consensus IL6GS score calculated by GSVA in ER + ILC and ER + NST tumors from TCGA, Mann-Whitney test **** p < 0.0001 in GraphPad Prism. Expression of the Consensus IL6GS score significantly and positively correlates with (D) IL6, (E) ESTIMATE stromal score (n = 109), and (F) Hallmark IL6-JAK-STAT3 signaling gene set (n = 191) in ER + ILC tumors, Spearman correlation in GraphPad Prism

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Acknowledgments

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