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Fig. 1

ID

ZDB-FIG-250526-60

Publication

Shi et al., 2025 - Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling

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Fig. 1

Drug screening in zebrafish identifies gastrodin as a pro-myelinating agent.

a Chemical structure of the TCM monomers (from ChemicalBook). b Schematic of drug screen pipeline. c Representative images depicting lateral view of the spinal cord in Tg(MBP:eGFP-CAAX) line at 5 dpf. Red box: location of zoomed-in example region (around 8–11 somites). d Mean fluorescence intensity of eGFP fluorescent intensity in the dorsal (above) and ventral (below) tracts of the spinal cord (n = 19–23 zebrafish). e Representative images depicting the dorsal tracts of the spinal cord in Tg(MBP:eGFP-CAAX) line at 5 dpf. Metformin serves as positive controls. f Mean fluorescence intensity of eGFP fluorescent intensity in the dorsal tracts of the spinal cord (n = 20 zebrafish). Data are represented as mean ± SEM, One-way ANOVA and Dunnett-t in d and f.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Pharmacol. Sin.