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Fig. 3

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ZDB-IMAGE-250519-9
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Figures for Semenova et al., 2025
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Fig. 3

Rescue of xrcc1 crispant cerebellar phenotype by parp1 deletion. (a) Volume of the lateral cerebellar plate (LCeP) in controls (ctl) and parp1 crispants (parp). N = 13,12. (b) Volume of the LCeP in control larvae (ctl), xrcc1 crispants (xrcc ; gRNA-t1/2) and xrcc1, parp1 double crispants (dbl ; xrcc1 gRNA-t1/2 and parp1 gRNA-t6/8). N = 16,14,12 respectively. * t-test p < 0.01. (c) qPCR for tp53 in controls (ctl), xrcc1 crispants (xrcc) and xrcc1, parp1 double crispants (dbl). * t-test p = 0.018, ** p = 0.001.

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