FIGURE

Fig. 4

ID

ZDB-FIG-250506-4

Publication

Wang et al., 2024 - Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Reprogramming miR-146b-snphb signaling promotes M-cell axon regeneration. A Schematic of the in vivo overexpression system of miR-146b. B Validation of vector-based miR-146b overexpression. The circle indicates neurons in the brain that express fluorescent signals. C MiR-146b levels were significantly increased by vector-based expression in vivo. D Quantitative RT-PCR showed that the expression of snphb was significantly reduced at 10 hpf in embryos overexpressing miR-146b. E, F Representative images of control (UAS-mCherry) and miR-146b OE axon regeneration results. Statistical results showed that miR-146b OE enhanced axon regeneration in zebrafish M-cells. Control: 322.1 ± 49.65 μm; miR-146b OE: 622.2 ± 42.48 μm. White asterisk denotes the injury site. Scale bar, 50 μm, *** P < 0.001, error bars indicate SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neurosci. Bull.