FIGURE

Fig. 3

ID

ZDB-FIG-250505-62

Publication

Shvartsburd et al., 2025 - Corticotropin-releasing hormone receptor 1 mediates the enhanced locomotor activity and metabolic demands to an acute thermal stress in adult zebrafish

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Fig. 3

Lack of Crhr1 inhibits thermal stress-mediated metabolic rate changes in zebrafish. (A) Metabolic rate of WT and crhr1−/− fish at 28°C and 33°C after 60 min of acclimation in the resting intermittent-flow respirometer. MO2 was calculated as the mean of the three lowest consecutive measurements from each individual. (B) Whole-body cortisol concentration of WT zebrafish exposed for 4 days to 325.4 μM metyrapone and sampled immediately after 90 min exposure to the resting intermittent-flow respirometer at 33°C. (C) Metabolic rate of untreated and metyrapone-treated WT fish at 33°C after 60 min of acclimation in the resting intermittent-flow respirometer. MO2 was calculated as in (A). (A) Different letters denote significant changes between treatment groups (Two-way ANOVA, Holm–Sidak post hoc test, p < 0.05). (B, C) Asterisks indicate significant difference (Student's t-test; *p < 0.05). Crhr1, corticotropin-releasing hormone receptor 1; KO, crhr1-/-; MO2, metabolic rate; WT, wildtype.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT crhr1^ca403/ca403
Conditions:	chemical treatment by environment: metyrapone, heat shock heat shock
Observed In:	whole organism aerobic respiration whole organism cortisol
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neuroendocrinol.