FIGURE

Fig. 5

ID

ZDB-FIG-250505-64

Publication

Shvartsburd et al., 2025 - Corticotropin-releasing hormone receptor 1 mediates the enhanced locomotor activity and metabolic demands to an acute thermal stress in adult zebrafish

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Fig. 5

Lack of Crhr1 affects thermal stress-mediated muscle energy metabolism. (A) Glucose concentration and (B) glycogen concentration measured in WT and crhr1−/− zebrafish epaxial muscle exposed to the novel tank test for 1 h at either 28°C or 33°C. (C) Transcript abundance of muscle gys1 and (D) pyg1, and (E) enzyme activity of hexokinase, (F) pyruvate kinase, and (G) lactate dehydrogenase measured in WT and crhr1−/− zebrafish epaxial muscle exposed to the novel tank test for 1 h at either 28°C or 33°C. Asterisks indicate a significant difference between treatment interaction (Two-way ANOVA, Holm–Sidak post hoc, *p < 0.05) or (G) main effects (Two-way ANOVA, *p < 0.05, **p < 0.01). Crhr1, corticotropin-releasing hormone receptor 1; gys1, glycogen synthase 1; KO, crhr1−/−; LDH, lactate dehydrogenase; pyg1, glycogen phosphorylase 1; WT, wildtype.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT crhr1^ca403/ca403
Condition:	heat shock
Observed In:	muscle glucose
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neuroendocrinol.