FIGURE

Fig. 1.

ID

ZDB-FIG-250502-1

Publication

Kanai et al., 2025 - The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1.

Sensitivity to YM is determined by eight conserved residues in a subset of Gq/11 family members. In zebrafish, Gq/11 family members are encoded by gnaq (Gq), gna11a (G11a), gna11b (G11b), gna14 (G14), gna14a (G14a) and gna15.1-15.4 (G15.1-15.4). Residue positions in Gq/11 family members that interact with YM are annotated with the Common Gα Numbering (CGN) system (Flock et al., 2015). YM-binding residues that are conserved in a subset of Gq/11 family members are shown in green boxes, while diverged residues are labeled in magenta. Superscript numbers indicate the amino acid position for the respective Gα protein. H1 and HA are α-helices of the Ras-like domain and the α helical domain, respectively, and S2 is a β-sheet of the Ras-like domain. These structures constitute the hydrophobic binding pocket for YM in a subset of Gq/11 family members.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development