ZFIN Image: Kanai et al., 2025, Fig. 1.

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Figure Caption

Fig. 1.

Sensitivity to YM is determined by eight conserved residues in a subset of Gq/11 family members. In zebrafish, Gq/11 family members are encoded by gnaq (Gq), gna11a (G11a), gna11b (G11b), gna14 (G14), gna14a (G14a) and gna15.1-15.4 (G15.1-15.4). Residue positions in Gq/11 family members that interact with YM are annotated with the Common Gα Numbering (CGN) system (Flock et al., 2015). YM-binding residues that are conserved in a subset of Gq/11 family members are shown in green boxes, while diverged residues are labeled in magenta. Superscript numbers indicate the amino acid position for the respective Gα protein. H1 and HA are α-helices of the Ras-like domain and the α helical domain, respectively, and S2 is a β-sheet of the Ras-like domain. These structures constitute the hydrophobic binding pocket for YM in a subset of Gq/11 family members.

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