FIGURE

FIGURE 7

ID

ZDB-FIG-250401-8

Publication

Wu et al., 2025 - SB218078 inhibits angiogenesis and epithelial-mesenchymal transition in breast cancer

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FIGURE 7

ZEB1-Independent Effects of SB218078 on Angiogenesis. (A) SB218078 inhibits EMT-related morphological changes in MDA-MB-231 cells. (B) Immunofluorescence analysis of protein levels of Vimentin and E-cadherin in MDA-MB-231 cells treated with either vehicle control (DMSO) or SB218078 (1 μM and 2 μM). (C) Schematic representation of the designed gRNA sequences for zeb1a, snail1a, twist1a, and GFP. (D) RNA expression levels of each target in zebrafish across different treatment groups. (E–G) Knockout of ZEB1 using the CRISPR system inhibits the vascular development of intersegmental vessels (ISVs) and subintestinal vessels (SIVs) in zebrafish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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