FIGURE

Figure 2.

ID

ZDB-FIG-250320-4

Publication

Doan et al., 2025 - Dock1 functions in Schwann cells to regulate development, maintenance, and repair

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Figure 2.

Remyelination following nerve injury is significantly reduced in dock1 MUTs. (A and B) TEM micrographs of control ZMBs from 4-mo-old WT dock1^+/+ and MUT dock1^{stl145/stl145} zebrafish. (C and D) TEM micrographs of WT dock1^+/+ and MUT dock1^{stl145/stl145} zebrafish showing regeneration and remyelination after transection, with remyelinated axons pseudocolored in blue. (E) Quantification of the number of myelinated axons in the ZMBs per 100 µm², n = 6 (WT dock1^+/+ control), 6 (WT dock1^+/+ regenerated), 6 (dock1^{stl145/stl145} MUT control), and 6 (dock1^{stl145/stl145} MUT regenerated). (F) Quantification of the g-ratio as it relates to the axon caliber of the remyelinated axons in the regenerated ZMBs, 28 days after transection, n = 6 (WT dock1^+/+ control), 6 (WT dock1^+/+ regenerated), 6 (dock1^{stl145/stl145} MUT control), and 6 (dock1^{stl145/stl145} MUT regenerated). (A–D) Scale bar = 1 µm. (E) Two-way ANOVA with Tukey’s multiple comparisons test. ****P < 0.0001; ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dock1^{stl145/stl145}
Condition:	amputation: maxillary barbel
Observed In:	maxillary barbel peripheral nervous system myelin formation
Stage:	Adult

Phenotype Detail

Acknowledgments

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