FIGURE

Figure 3.

ID

ZDB-FIG-250320-5

Publication

Doan et al., 2025 - Dock1 functions in Schwann cells to regulate development, maintenance, and repair

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Figure 3.

SC-specific Dock1 MUTs present with multiple defects in peripheral nerves. (A) Western blot (kD) showing sciatic nerve Dock1 and β-actin protein levels from control and Dock1 cKO animals and quantification of normalized protein levels. (B and C) TEM micrographs of sciatic nerves from Dhh^Cre+;Dock1^+/+ control and littermate Dhh^Cre+;Dock1^fl/fl cKO mice at P3. (D) Quantification of the g-ratio as it relates to axon caliber, n = 6 mice, 4 images per nerve (WT); 6 mice, 4 images per nerve (cKO). (E)Dock1 cKO MUT SCs display abnormal cytoplasmic protrusions that extend in multiple directions (red arrows). (F) Trails of basal lamina found in Dock1 cKO MUTs are observed in regions devoid of SC cytoplasm (red arrowheads). (B and C) Scale bar = 4 µm. (E and F) Scale bar = 1 µm. Source data are available for this figure: SourceData F3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Biol.