PUBLICATION
Dock1 functions in Schwann cells to regulate development, maintenance, and repair
- Authors
- Doan, R.A., Monk, K.R.
- ID
- ZDB-PUB-250320-1
- Date
- 2025
- Source
- The Journal of cell biology 224: (Journal)
- Registered Authors
- Monk, Kelly
- Keywords
- none
- MeSH Terms
-
- rac1 GTP-Binding Protein*/genetics
- rac1 GTP-Binding Protein*/metabolism
- Neuropeptides
- Guanine Nucleotide Exchange Factors/genetics
- Guanine Nucleotide Exchange Factors/metabolism
- rac GTP-Binding Proteins/genetics
- rac GTP-Binding Proteins/metabolism
- Animals
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Myelin Sheath*/metabolism
- Signal Transduction
- Zebrafish*/genetics
- Zebrafish*/metabolism
- Nerve Regeneration/genetics
- Schwann Cells*/metabolism
- Mice
- PubMed
- 40105697 Full text @ J. Cell Biol.
Citation
Doan, R.A., Monk, K.R. (2025) Dock1 functions in Schwann cells to regulate development, maintenance, and repair. The Journal of cell biology. 224:.
Abstract
Schwann cells, the myelinating glia of the peripheral nervous system (PNS), are critical for myelin development, maintenance, and repair. Rac1 is a known regulator of radial sorting, a key step in developmental myelination. Previously, in zebrafish, we showed that the loss of Dock1, a Rac1-specific guanine nucleotide exchange factor, resulted in delayed peripheral myelination during development. Here, we demonstrate that Dock1 is necessary for myelin maintenance and remyelination after injury in adult zebrafish. Furthermore, Dock1 performs an evolutionarily conserved role in mice, functioning cell autonomously in Schwann cells to regulate the development, maintenance, and repair of peripheral myelin. Pharmacological and genetic manipulation of Rac1 in larval zebrafish, along with the analysis of active Rac1 levels in developing Dock1 mutant mouse nerves, revealed an interaction between these two proteins. We propose that the interplay between Dock1 and Rac1 signaling in Schwann cells is required to establish, maintain, and facilitate repair and remyelination within the PNS.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping