FIGURE

Fig. 7

ID

ZDB-FIG-250304-27

Publication

Sebo et al., 2025 - Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation

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Fig. 7

Activation of Wnt/?-catenin signaling in NPCs causes neuroinflammation. (a) Representative images of gfap:rtTA, TRE:?-cat*-EGFP, mfap:tdTomato larvae or wild type siblings (Con.) at 3 dpf, treated with indicated Dox concentrations. Magnified frames (5?�?Zoom) highlight microglia/macrophages in the hindbrain (Hb) and spinal cord (Sc). The CNS is outlined by yellow dotted boxes. (b, c) Quantification of mfap+ cells within the CNS (b) and in the whole larva (c) of larvae shown in (a) (n?=?6 for all conditions). p-values were calculated for comparisons of all groups using the parametric one-way analysis of variance (ANOVA) with Tukey HSD post hoc test (no label?=?not significant). Data are shown as mean?�?standard deviation. (d) Representative lateral images of gfap:rtTA, TRE:?-cat*-EGFP, mpx:mCherry larvae or wild type siblings (Con.) at 3 dpf, treated with indicated Dox concentrations. Magnified frames (5?�?Zoom) highlight neutrophils in the hindbrain (Hb) and spinal cord (Sc). The CNS is outlined by yellow dotted boxes. (e, f) Quantification of mpx+ cells within the CNS (e) and in the whole larva (f) of larvae shown in (d) (n?=?6 for all conditions). p-values were calculated for comparisons of all groups using the parametric one-way analysis of variance (ANOVA) with Tukey HSD post hoc test (no label?=?not significant). Data are shown as mean?�?standard deviation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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