FIGURE

Fig 2

ID

ZDB-FIG-250207-62

Publication

Widziolek et al., 2025 - Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance

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Fig 2

Myeloid cell-depleted zebrafish larvae are more susceptible to Porphyromonas gingivalis (Pg) infection.

(A) Kaplan-Meyer survival plot of pu.1 MO-treated or PBS-injected control zebrafish larvae upon systemic infection with the wild-type Pg W83 or ΔK/R-ab. Survival plots were analysed by log-rank test.*p≤0.05,***p≤0.001; hpi- hours post infection. (B) Representative images of the yolk and tail region of pu.1 MO-treated and untreated zebrafish larvae 2 hpi with fluorescein-SE (green) and pHrodo (red) dual-stained ΔK/R-ab. The untreated larvae display orange dots (white arrows) representing phagocytosed (phagosome acidified) ΔK/R-ab. Phagocytosed ΔK/R-ab were not detected in pu.1 MO due to removal of myeloid cells. White dashed lines indicate yolk or tail areas. Boxes show zoomed regions of the images. h-heart. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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