FIGURE

Fig. 4

ID

ZDB-FIG-250115-4

Publication

Shipman et al., 2024 - Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants

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Fig. 4

Impaired vision in vps4aT248I mutants. A, 5 dpf vps4aT248I mutants (N = 10) have a severely reduced optomotor response compared with wild-type siblings (N = 12); Mann?Whitney test; p < 0.0001 (exact). B, Decreased b-wave amplitude in ERGs of 5?6 dpf vps4aT248I mutants (N = 34) in comparison with wild-type siblings (N = 23) occurs at brighter light intensities (log ?4 to log 0); Kruskal?Wallis test (log 0, p < 0.0001; log ?1, p < 0.0001; log ?2, p < 0.0001; log ?3, p = 0.0014; log ?4, p = 0.1989). C, HCR RNA-FISH of gap43, jun, and opn1sw1 in the eye of vps4aT248I mutants compared with wild-type siblings. Pr, photoreceptors; Rg, retinal ganglion cells, lens.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurosci.