Gene
jun
- ID
- ZDB-GENE-030131-7859
- Name
- Jun proto-oncogene, AP-1 transcription factor subunit
- Symbol
- jun Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Contributes to DNA-binding transcription factor activity and beta-catenin binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including canonical Wnt signaling pathway; response to cadmium ion; and response to methylmercury. Part of transcription regulator complex. Is expressed in several structures, including digestive system; hematopoietic system; mesoderm; musculature system; and sensory system. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77457 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gan et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021409Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-jun | N/A | Fong et al., 2005 |
| MO2-jun | N/A | (3) |
| MO3-jun | N/A | Gan et al., 2008 |
| MO4-jun | N/A | (2) |
| MO5-jun | N/A | Li et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004827 | Basic-leucine zipper domain |
| Domain | IPR005643 | Jun-like transcription factor |
| Family | IPR002112 | Transcription factor Jun |
| Family | IPR050946 | AP-1 Transcription Factor bZIP |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AP-1 Transcription Factor bZIP | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | Jun-like transcription factor | Transcription factor Jun | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NZT5 | InterPro | 308 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gfap:jun-NEXS-Venus) |
| 1 | Becker et al., 2023 | ||
| Tg(hsp70l:dnjun-2A-mCherry,cryaa:GFP) |
| 1 | Peng et al., 2020 | ||
| Tg(hsp70l:jun-2A-mCherry,cryaa:GFP) |
| 1 | Peng et al., 2020 | ||
| Tg(hsp70l:jundn-mCherry) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(jun-Mmu.Fos:EGFP) |
|
| 2 | Lickwar et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-86E18 | ZFIN Curated Data | |
| Encodes | EST | fj36h07 | ||
| Encodes | cDNA | MGC:65863 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77457 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199987 (1) | 1940 nt | ||
| Genomic | GenBank:CR392368 (2) | 87973 nt | ||
| Polypeptide | UniProtKB:Q6NZT5 (1) | 308 aa |
- Li, Q., Wu, L., Wang, G., Zheng, F., Sun, J., Zhang, Y., Li, Z., Li, L., Sun, B. (2024) Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota. Foods (Basel, Switzerland). 13(2):
- Shipman, A., Gao, Y., Liu, D., Sun, S., Zang, J., Sun, P., Syed, Z., Bhagavathi, A., Smith, E., Erickson, T., Hill, M., Neuhauss, S., Sui, S.F., Nicolson, T. (2024) Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(50):
- Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Zhou, X., Lian, K., Jia, J., Zhao, X., Duan, P., Huang, J., Shi, Y. (2024) Functions of Epimedin C in a zebrafish model of glucocorticoid-induced osteoporosis. Journal of Cellular and Molecular Medicine. 28:e18569e18569
- Becker, C.J., Cigliola, V., Gillotay, P., Rich, A., De Simone, A., Han, Y., Di Talia, S., Poss, K.D. (2023) In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development (Cambridge, England). 150(24):
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Ahmed, M., Kojima, Y., Masai, I. (2022) Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation. eLIFE. 11:
- Li, Y., Wang, R., Li, Y., Sun, G., Mo, H. (2022) Protective effects of tree peony seed protein hydrolysate on Cd-induced oxidative damage, inflammation and apoptosis in zebrafish embryos. Fish & shellfish immunology. 126:292-302
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