FIGURE

Fig. 3

ID

ZDB-FIG-250106-11

Publication

Dernov?ek et al., 2024 - First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo

Other Figures

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Fig. 3

Predicted binding mode of (R)-3 (in yellow sticks) in the (a) ATP-binding site of the human topoisomerase II? (PDB entry: 4R1F, in green cartoon), and (b) allosteric binding site at the Hsp90? C-terminal domain (PDB entry: 5FWK, protomer A in grey cartoon, protomer B in cyan cartoon). Hydrogen bonds between the protein and (R)-3 are presented as black dashed lines.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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