FIGURE
Fig. 2
- ID
- ZDB-FIG-250106-10
- Publication
- Dernov?ek et al., 2024 - First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo
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Fig. 2
Overlay of compound 3 with the structure-based pharmacophore model derived from the most representative molecular dynamics binding mode of inhibitor in the C-terminal domain binding site of the Hsp90? dimer [28] (PDB entry: 5FWK). Blue star represents a positively ionizable pharmacophore feature, green arrow a hydrogen bond donor pharmacophore feature, yellow spheres hydrophobic pharmacophore feature and grey spheres represent excluded volumes. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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