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Figure Caption
Fig. 3 Predicted binding mode of (R)-3 (in yellow sticks) in the (a) ATP-binding site of the human topoisomerase II? (PDB entry: 4R1F, in green cartoon), and (b) allosteric binding site at the Hsp90? C-terminal domain (PDB entry: 5FWK, protomer A in grey cartoon, protomer B in cyan cartoon). Hydrogen bonds between the protein and (R)-3 are presented as black dashed lines.
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