FIGURE

Figure 6

ID

ZDB-FIG-241212-36

Publication

Zheng et al., 2024 - Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome

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Figure 6

InP/ZnS QDs embryonic exposure promoted the differentiation of PR(UV) to PR(RGB) in zebrafish. a‐e) The bioinformatics analysis was based on the data from scRNA‐seq. a) KEGG pathway analysis of the DEGs in PR(UV) cells. b) The GSEA of PR(UV) cells. c) KEGG pathway analysis of the DEGs in PR(RGB) cells. d) The GSEA of PR(RGB) cells. e) The single‐cell RNA velocity of four types of PR cells in the control and InP/ZnS QDs group, respectively, using by cell velocity. The red cycle indicates the differentiation of PR(UV) to PR(RGB). f) Fluorescence triple staining assay (TSA) was used to track PR(UV), PR(R), and PR(GB), respectively. The white arrowheads display the co‐location of PR(UV) with PR(R) or PR(GB), suggesting the differentiation of PR(UV) to PR(RGB) caused by InP/ZnS QDs exposure. The images were captured by confocal microscopy. Scale bar, 10 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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