FIGURE

Figure 3

ID

ZDB-FIG-241212-33

Publication

Zheng et al., 2024 - Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome

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Figure 3

InP/ZnS QDs embryonic exposure induced many types of cell injury and impaired phototransduction in zebrafish retinas using bulk RNA‐seq. After exposure to InP/ZnS QDs, the zebrafish eyes at 72 hpf were collected to perform RNA‐seq, n = 3. a) The PCA result of control, 0.1 and 1 mg L⁻¹ InP/ZnS QDs. b) Venn diagram of the overlapped DEGs in the 0.1 and 1 mg L⁻¹ groups compared to the control with 0.5‐fold cutoff and p < 0.05. c,d) KEGG pathway analysis of the DEGs in 0.1 c) and 1 mg L⁻¹ groups d), respectively. e) The heatmap of DEGs in the ribosome, ferroptosis, oxidative phosphorylation, and phototransduction pathways. Ferro: ferroptosis, OP: oxidative phosphorylation, PT: phototransduction. f) The qPCR was performed to validate the DEGs determined from RNA‐seq, n ≥ 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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