FIGURE

Figure 1

ID

ZDB-FIG-241114-17

Publication

Ranjan et al., 2024 - SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

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Figure 1

Syntenic cardiovascular conserved associated region - 6 (scar-6) is a novel conserved lncRNA gene.

(A) Schematic of pipeline used for subset selection of syntenic lncRNAs with its neighboring protein-coding genes associated in the cardiovascular system. Overview of conserved syntenic block depiction of scar-6 locus between human and zebrafish. (B, C) UCSC genome browser snapshot of scar-6 locus in zebrafish and human. Strand-specific PCR and 3’RACE confirmed the transcript to be antisense to f10 in zebrafish. (D) Expression profile of scar-6 transcript (in TPM) across 8 different developmental stages of zebrafish using publically available RNA-seq data. (E) Expression profile of scar-6 transcript (in TPM) across 12 different tissues using publically available RNA-seq data. (F) Whole mount in situ hybridization expression analysis of scar-6, f10, and prozb transcripts of zebrafish in 3 dpf embryo. Sense probes were used as controls for f10 and prozb. No probe control was used for scar-6. Black arrow head denotes expression in liver and heart. 4× magnification scale bar = 500 μm. Source data are available online for this figure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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