FIGURE

Fig. 6

ID

ZDB-FIG-241022-54

Publication

Ding et al., 2024 - Inhibition of PNCK inflames tumor microenvironment and sensitizes head and neck squamous cell carcinoma to immune checkpoint inhibitors

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Fig. 6

Heterogeneity analysis of T cell subtypes. (a, b) UMAP analysis shows the distribution of T cell subtypes in different samples. Each point represents a single cell, colored by its subtype. (c) Bubble plots showing the expression of commonly used marker genes for each T cell subtype, used for annotating cell subtypes. The size of the bubble represents the percentage of cells expressing the marker gene, and the color intensity indicates the expression level. (d) UMAP analysis shows the distribution of different T cell subtypes. Different colors represent different T cell subtypes. (e) Proportion of each T cell subtype in the WT and knockdown groups. Bar graphs illustrate the percentage of each subtype in the two groups. (f) Multiplex immunofluorescence probed the content of Tpex cells (TCF7+ PD1+ CD8+) in PNCK-KD samples. (g) KEGG functional enrichment analysis of DEGs in the Tpex cell subtype. The bar graph shows the top enriched pathways, with the length of the bar indicating the enrichment score. DEGs, differentially expressed genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Immunother Cancer