FIGURE

Fig. 4

ID

ZDB-FIG-241022-52

Publication

Ding et al., 2024 - Inhibition of PNCK inflames tumor microenvironment and sensitizes head and neck squamous cell carcinoma to immune checkpoint inhibitors

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Knockdown of the Pnck gene induces antitumor immune response. (a) Volcano plot showing DEGs in the sequencing results, including upregulation of genes encoding immune cell chemotactic factors, like Ccl24, Ccr10, Vtcn1, Ackr4 and Cxcr2. Differentially expressed genes were identified with the threshold of |log2(fold change)| >1 and false discovery rate (FDR)<0.05. (b) Heatmap showing the enrichment and upregulation of immune-related pathways in the Pnck-KD group. (c) GSEA enrichment analysis of complement and cytokine-related pathways in the PNCK low-expression group, and GSEA enrichment of cell cycle and DNA repair-related pathways in the high-expression group. (d) Immunohistochemistry demonstrated the expression levels of CD4, CD8, and CD163 in PNCK high and low groups. (e) Infiltration abundance of CD8 T cells in mouse tumors in the WT and Pnck-KD group (n=3 biologically independent samples).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Immunother Cancer