FIGURE
Figure 7.
- ID
- ZDB-FIG-241017-59
- Publication
- Massoz et al., 2024 - Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish
- Other Figures
- All Figure Page
- Back to All Figure Page
Figure 7.
Model of calcineurin (CaN) action on ductal progenitors to regenerate beta cells. Under physiological conditions, the behavior of the ductal progenitors is determined by Notch signaling. CaN is active in these progenitors and enable a proper control between proliferation and differentiation. When CaN in repressed, more ductal progenitors enter in the cell cycle (2 dpt) and switch to a mode of proliferation leading to differentiation of the two daughter cells (4 dpt), as more pro-endocrine cells are formed. The result is a exhaustion of the progenitors and a premature beta cell differentiation (10 dpt). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Elife