FIGURE

Fig. 2

ID

ZDB-FIG-240903-111

Publication

Lints et al., 2024 - Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia

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Fig. 2

HSPC-targeted expression of human oncogenic 9a and NRAS, or NRAS alone, induces sickness and mortality in adult zebrafish. (A) Kaplan–Meier Survival Curve of F0 transgenic populations generated by injection of the expression constructs shown in Fig. 1A. Data shown corresponds to analyses of 2 to 4 injected batches per genotype. Numbers of animals per genotype, n: Wild type (WT), 60; GFP, 203; 9a, 132; NRAS, 131; 9a+NRAS, 384. Statistical test: Log-rank (Mantel-Cox) test: **P=0.009; ****P<0.0001; ns, not significant. (B–D) Whole animal images (stitched montages) of (B) healthy WT; (C) sick NRAS and (D) sick 9a+NRAS F0 animals. Bleeding from gills (arrowhead) is seen only in sick oncogenic transgenics.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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