FIGURE

Fig. 6

ID

ZDB-FIG-240829-67

Publication

Camussi et al., 2024 - Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models

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Fig. 6

Effects of valproic acid (VPA) on WT-AB larvae mRNA gene expression values at 120 h post-fertilisation (hpf) (n = 90 per group). (A,B) Data analysis showed a significant upregulation of pro-inflammatory cytokines (IL-1β and IL-6) in 50 μM VPA-treated larvae compared with controls (* p ≤ 0.05, t-test with Welch correction). (C,D) Anti-inflammatory cytokines (IL-4 and IL-10) were downregulated in 50 μM VPA-treated larvae compared with controls (* p ≤ 0.05, t-test with Welch correction). (E–H) Neurogenesis- and neuronal activation-related genes (nlgn3, nrxn1, ngf, and c-fos) were downregulated in 50 μM VPA-treated larvae compared with controls (* p ≤ 0.05 or ** p ≤ 0.01, t-test with Welch correction). (I) Expression of the VPA-target gene (hdac4) was downregulated in 50 μM VPA-treated larvae compared with controls (* p ≤ 0.05, t-test with Welch correction). Data are represented as means ± SEM. Abbreviations: ns = not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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