FIGURE

Figure 2.

ID

ZDB-FIG-240821-39

Publication

Karampelias et al., 2024 - Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration

Other Figures

All Figure Page

Back to All Figure Page

Figure 2.

Transcriptomic changes in hepatocytes after β-cell ablation.

(A) Schema showing the experimental design to identify transcriptional changes in hepatocytes after β-cell ablation in 2-mo-old zebrafish. (B) Glucose measurements of the 2-mo-old zebrafish used for hepatocyte isolation. Measurements were made before liver dissection. n = 5–9. A Mann–Whitney test was used to assess significance. **P = 0.0045. (C) Log₂ fold change plot showing the up-regulated and down-regulated genes in hepatocytes after β-cell ablation. The significantly differentially expressed genes (P adj < 0.05) are highlighted as red dots. (C, D, E, F) Statistical overrepresentation analysis of the down-regulated genes from (C) using the PantherDB tool. (D, E, F) Fold enrichment of the significantly enriched processes (D), molecular function (E), and Reactome pathways (F) is shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Life Sci Alliance