FIGURE

Fig. 8

ID

ZDB-FIG-240812-20

Publication

Guo et al., 2024 - Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability

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Fig. 8

Schematic working model for the role of Tmem106bb in the maintenance of HSPC numbers and functions during zebrafish embryogenesis. Tmem106bb is required for the self-renewal and maintenance of differentiation potentials of HSPCs. In tmem106bb?/? KO zebrafish, HSPCs exhibit impaired self-renewal and disrupted differentiation. The underlying molecular mechanism is that TMEM106B acts as a chaperone for LAMP2A, and loss of TMEM106B increases the degradation of LAMP2A, which impairs CMA and causes abnormal HSPC proliferation and differentiation.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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