FIGURE
Fig. 8
- ID
- ZDB-FIG-240812-20
- Publication
- Guo et al., 2024 - Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability
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Fig. 8
Schematic working model for the role of Tmem106bb in the maintenance of HSPC numbers and functions during zebrafish embryogenesis. Tmem106bb is required for the self-renewal and maintenance of differentiation potentials of HSPCs. In tmem106bb−/− KO zebrafish, HSPCs exhibit impaired self-renewal and disrupted differentiation. The underlying molecular mechanism is that TMEM106B acts as a chaperone for LAMP2A, and loss of TMEM106B increases the degradation of LAMP2A, which impairs CMA and causes abnormal HSPC proliferation and differentiation. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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