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Figure Caption
Fig. 8 Schematic working model for the role of Tmem106bb in the maintenance of HSPC numbers and functions during zebrafish embryogenesis. Tmem106bb is required for the self-renewal and maintenance of differentiation potentials of HSPCs. In tmem106bb−/− KO zebrafish, HSPCs exhibit impaired self-renewal and disrupted differentiation. The underlying molecular mechanism is that TMEM106B acts as a chaperone for LAMP2A, and loss of TMEM106B increases the degradation of LAMP2A, which impairs CMA and causes abnormal HSPC proliferation and differentiation.
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Full text @ FASEB J.