FIGURE

Fig. 6

ID

ZDB-FIG-240731-6

Publication

Xie et al., 2024 - Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling

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Fig. 6

GTP compensation partially restored the hearing impairment caused by myo7aa deficiency. (A–D) YO-PRO-1 staining results of inner ear hair cells were observed in sibling (A), myo7aa−/− (B), GTP-compensated sibling (C), and myo7aa−/− (D) embryos at 5 dpf. (E,F) The relative expression of some genes in the cellular endocytic pathway (E) and G protein signaling pathway (F) is examined between WT, myo7aa−/−, and GTP-compensated myo7aa−/− embryos at 3 dpf is examined. (G,H) The movement distance (G) and reaction speed (H) of wild WT, myo7aa−/−, and GTP-compensated myo7aa−/− embryos are measured within 0.3 s after acoustic stimulation at 5 dpf are measured. n = 20; mean with SEM; with ANOVA, ****p < 0.0001, **p < 0.01, *p < 0.05, nsp > 0.05.

Expression Data

Genes:	arhgef40 dab2ipa grk3 kif5bb rab11fip3
Fish:	TU myo7aa^hn13/hn13 (TU) myo7aa^hn14/hn14 (TU)
Condition:	chemical treatment by environment: GTP
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myo7aa^hn13/hn13 (TU) myo7aa^hn14/hn14 (TU)
Conditions:	chemical treatment by environment: GTP vibration chemical treatment by environment: ATP, vibration chemical treatment by environment: GTP, vibration
Observed In:	auditory behavior inner ear hair cell startle response whole organism
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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