FIGURE

Fig. 3

ID

ZDB-FIG-240731-3

Publication

Xie et al., 2024 - Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling

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Fig. 3

Loss of myo7aa causes hearing impairment. (A,B) YO-PRO-1 fluorescence staining results of wild-type and myo7aa mutant hair cells at 5 dpf, arrowheads indicate zebrafish inner ear (red) and lateral line hair cells (blue); (C,D) YO-PRO-1 fluorescent staining results of ear hair cells in wild-type and myo7aa mutant at 5 dpf, arrowheads indicate zebrafish inner ear hair cells (red) and otoliths (yellow). These results demonstrate the impact of myo7aa loss on the function of hair cells in the ear, leading to hearing impairment. Additionally, the results of genotype identification of embryos shown in (B,D) are presented. (E) Genotyping results of line2. M is DNA marker, WT indicates wild type, 1–8 are embryos shown in (B,D). (F,G) The movement distance (F) and reaction speed (G) of wild type and myo7aa mutant within 0.3 s after acoustic stimulation at 5 dpf are measured; n = 20; mean with SEM; with t-test, **** indicates a p-value <0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myo7aa^hn13/hn13 (TU) myo7aa^hn14/hn14 (TU)
Condition:	vibration
Observed In:	auditory behavior inner ear hair cell lateral line hair cell startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.