Gene

grk3

ID

ZDB-GENE-030616-382

Name

G protein-coupled receptor kinase 3

Symbol

grk3 Nomenclature History

Previous Names

GRK2/3 (1)
adrbk2 (1)
si:dz221d18.1

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Exhibits protein kinase activity. Involved in several processes, including heart rudiment formation; muscle cell development; and smoothened signaling pathway. Is expressed in several structures, including heart; immature eye; nervous system; notochord; and tail bud. Orthologous to several human genes including GRK3 (G protein-coupled receptor kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grk3 Human Ortholog

No data available

Associated With grk3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR016137	RGS domain
Family	IPR000239	GPCR kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	GPCR kinase	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	RGS domain	RGS domain superfamily	RGS, subdomain 2	Serine/threonine-protein kinase, active site
UniProtKB:B5LZ08 InterPro	688
UniProtKB:A0A2R8QPB8 InterPro	701

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adrbk2-001 (1)	Havana	1,776 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grk3-201 (1) Ensembl	Ensembl	834 nt	Select Tool
mRNA	grk3-202 (1) Ensembl	Ensembl	2,392 nt	Select Tool ZFIN BLAST
mRNA	grk3-203 (1) Ensembl	Ensembl	2,106 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-grk3	polyclonal	grk3		Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations