Gene
arhgef40
- ID
- ZDB-GENE-110623-2
- Name
- Rho guanine nucleotide exchange factor (GEF) 40
- Symbol
- arhgef40 Nomenclature History
- Previous Names
-
- zmp:0000001199
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Is expressed in male organism. Orthologous to human ARHGEF40 (Rho guanine nucleotide exchange factor 40).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR055251 | SOS1/NGEF-like, PH domain |
| Family | IPR052231 | Rho GEF and signaling-related domain-containing protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dbl homology (DH) domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Rho GEF and signaling-related domain-containing protein | SOS1/NGEF-like, PH domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7F579 | InterPro | 1752 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef40-201
(1)
|
Ensembl | 6,047 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-142D6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001919569 (1) | 12893 nt | ||
| Genomic | GenBank:AL929105 (1) | 178797 nt | ||
| Polypeptide | UniProtKB:E7F579 (1) | 1752 aa |
- Comparative Orthology
- Alliance
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Atienzar-Aroca, R., Ferre-Fernández, J.J., Tevar, A., Bonet-Fernández, J.M., Cabañero, M.J., Ruiz-Pastor, M.J., Cuenca, N., Aroca-Aguilar, J.D., Escribano, J. (2022) Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish. International Journal of Molecular Sciences. 23(17)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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