FIGURE

Figure 3

ID

ZDB-FIG-240729-253

Publication

Filippini et al., 2024 - Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish

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Figure 3

LRRK2 KO mouse brains displayed alterations of MBP+ striosomes. (a) Maximum intensity Z-projection confocal images of 13-month-old LRRK2 WT and KO mice immunostained for MBP. LRRK2 WT: (a’) Z = 3 mm, (a’’) Z = 4 mm; LRRK2 KO: (a’) Z = 3 mm, (a’’) Z = 2.33 mm. Scale bars 20 µm. (b) Cumulative frequency distributions of MBP negative signal in LRRK2 WT and LRRK2 KO mice (LRRK2 WT = 249 striosomes and LRRK2 KO = 242 striosomes; ** p < 0.01, Kolmogorov–Smirnov test, n = 3 animals per group).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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