FIGURE

Figure 3

ID

ZDB-FIG-240727-12

Publication

Sumathipala et al., 2024 - Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder

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Figure 3

Syngap1ab larvae show short-term habituation to vibrational stimuli and more movement in response to stronger stimuli. (A) A schematic representation of the habituation assay (modified from Wolman et al., 2015) is shown. (B) Mean ± standard error movement velocity of WT and syngap1ab+/− larvae 1 s post-vibration. (C) Habituation indices were calculated per larva by subtracting the mean velocity post-habituation (taps 41–50) from the mean velocity pre-habituation (taps 11–20). (D) The median velocity mm/s moved per phase is shown for WT and syngap1ab+/− larvae. (E) Percentage response per phase is shown for WT and syngap1ab+/− larvae. A mixed effects model of genotype and phase was conducted and when p < 0.05 was followed by a Tukey’s multiple comparison test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.