FIGURE

Figure 1

ID

ZDB-FIG-240727-10

Publication

Sumathipala et al., 2024 - Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder

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Figure 1

Zebrafish syngap1a and syngap1b isoforms. NCBI database searches revealed (A) five syngap1a (X1–X5) and (B) eleven syngap1b isoforms (X0, X2–5, X7–11, and X13) with evidence of expression. Transcriptional start sites are shown with arrows and stop codons are shown using an asterisk (*). Alternative splice sites are shown either using a dot (if the exon is missing <10 bp) or a box (if the difference is >10 bp). Isoform X*, box and connecting line colors denote exons and stop codons that are unique to the different isoforms. Black boxes and lines represent common exons/transcription start sites. The insert below the syngap1b X5 shows ten of eleven C-term amino acids (underlined) are identical to the human α1 isoform, with the PDZ-interacting domain shown in red.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.