Figure 3

Figure 3

Syngap1ab larvae show short-term habituation to vibrational stimuli and more movement in response to stronger stimuli. (A) A schematic representation of the habituation assay (modified from Wolman et al., 2015) is shown. (B) Mean ± standard error movement velocity of WT and syngap1ab+/− larvae 1 s post-vibration. (C) Habituation indices were calculated per larva by subtracting the mean velocity post-habituation (taps 41–50) from the mean velocity pre-habituation (taps 11–20). (D) The median velocity mm/s moved per phase is shown for WT and syngap1ab+/− larvae. (E) Percentage response per phase is shown for WT and syngap1ab+/− larvae. A mixed effects model of genotype and phase was conducted and when p < 0.05 was followed by a Tukey’s multiple comparison test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.